GE2

D, Kepley CL, Zhang M, Zhang K, Saxon A. A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Nat Med. 8:518-21 (2002).
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Yamada, T, Zhu, DC, Zhang, K. Saxon, A. Inhibition of IL-4-induced class switch recombination by a human Ig Fc gamma -Fc epsilon chimeric protein, J. Biol. Chem. 278:32818-24 (2003).
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Kepley, CL, Zhang, K, Zhu, D, Saxon, A. FcεRI-FcγRII co-aggregation inhibits IL-16 production from human langerhans-like dendritic cells. Clinical Immunol. 108:89-94 (2003).
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Kepley, CL, Taghavi, S, Mackay, G, Zhu, D, Morel, PA, Zhang, K, Ryan, JJ, Satin, LS, Zhang, M, Pandolfi, PP, Saxon, A. Co-aggregation of FcγRII with FcεRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes, J. Biol. Chem. 279:35139-49 (2004).
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Zhang K, Kepley CL, Terada T, Zhu D, Perez H, Saxon A. Inhibition of allergen-specific IgE reactivity by a human Ig Fc gamma-Fc epsilon bifunctional fusion protein. J Allergy Clin. Immunol. 114:321-27 (2004).
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Zhu D, Kepley CL, Zhang M, Zhang K, Saxon A. A novel human immunoglobulin Fcγ-Fcε bifunctional fusion protein inhibits FcεRI-mediated degranulation. Nat Med. 11:446-49 (2005).
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Allen LC, Kepley CL, Saxon A, Zhang K. Modifications of an Fcγ-Fcε fusion protein alter its effectiveness in the inhibition of FcεRI-mediated functions. J Allergy Clin. Immunol. 120:462-68 (2007).
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Mertsching E, Bafetti L, Perper S, Giza K, Allen LC, Negrou E, Hathaway K, Hopp J, Chung J, Perret D, Shields M, Saxon A, Kehry MR. A mouse Fc gamma-Fc epsilon protein that inhibits mast cells through activation of FcgammaRIIB, SH2 domain-containing inositol phosphatase 1, and SH2 domain-containing protein tyrosine phosphatases. J Allergy Clin. Immunol. 121:441-47 (2008).
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Allergen-specific vaccines

Zhu D, Kepley CL, Zhang K, Terada T, Yamada T, Saxon A. A chimeric human-cat fusion protein blocks cat-induced allergy. Nat Med. 11:446-9 (2005).
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Terada T, Zhang K, Belperio J, Londhe V, Saxon A. A chimeric human-cat Fc gamma-Fel d1 fusion protein inhibits systemic, pulmonary, and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1, the major cat allergen. Clin Immunol. 120:45-56 (2006).
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Reviews

Saxon A, Zhu D, Zhang K, Allen LC, Kepley CL. Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases. Curr Opin Allergy Clin Immunol. 4:563-68 (2004).
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Zhang K, Zhu D, Kepley CL, Terada T, Saxon A. Chimeric human Fc gamma-allergen fusion proteins in the prevention of allergy. Immunol. Allergy Clin. North Am. 27:93-103 (2007).
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Saxon A, Kepley CL, Zhang K. “Accentuate the negative, eliminate the positive”: Engineering allergy therapeutics to block allergic reactivity through negative signaling. J Allergy Clin. Immunol. 121:320-5 (2008).
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