Scientific Advisors

Andrew Saxon, MD


A founder and CSO of Tunitas, Dr. Saxon is Professor and former Chief of Clinical Immunology and Allergy at the UCLA School of Medicine. Dr. Saxon is a world-renowned expert in the cellular and molecular biology of human allergic disease. In addition to the developing the platforms Tunitas has licensed, Dr. Saxon and his collaborators have made seminal discoveries on the mechanisms that control human allergic antibody (IgE) production and the role of environmental factors in development of the allergic response. Dr. Saxon served as the chairman of the Allergy and Asthma Section of the Immune Tolerance Network for more than a decade and has served in a wide range of capacities for peer reviewed funding organizations across the globe. Andy graduated from Dartmouth College and received his MD degree from Harvard University. Following an internship in internal medicine at UCLA Harbor General Hospital and postdoctoral training in Microbiology/Immunology, he founded the Division of Clinical Immunology/Allergy in the Department of Medicine at UCLA, where he served as Chief of the Division for nearly 30 years.


Jonathan Corren, MD
Dr. Corren is currently a faculty member in the Department of Medicine at the UCLA School of Medicine, has private practice and conducts clinical trials and translational research. He completed a fellowship in Allergy and immunology at the National Jewish Center for Immunology and Respiratory Medicine, where he also served as a faculty member and clinical investigator. As a faculty member at UCLA, he served as Director of Clinical Allergy Services at the UCLA Center for Health Sciences, the Nasal and Sinus Disease Center, and the Fellowship Training Program in Clinical Immunology and Allergy. Dr. Corren’s current clinical trial interests and translational research focus primarily on the role of cytokine inhibition in severe asthma, new methods of allergy immunotherapy and development of new provocational models for studying allergic rhinitis.


Lawrence Schwartz, MD, PhD
Lawrence Schwartz is the Charles & Evelyn Thomas Professor of Medicine and Chair, Division of Rheumatology Allergy & Immunology at Virginia Commonwealth University (VCU). He received his MD and PhD degrees from Washington University and then completed internal medicine residency (Barnes Hospital) and fellowships in allergy/immunology and rheumatology (Brigham & Womens) and diagnostic laboratory immunology (VCU). He joined the Harvard faculty before moving to VCU in 1983. Dr. Schwartz’s lab has made fundamental discoveries about human mast cells and basophils. Accomplishments include the discovery and characterization of human α/β tryptases, development of in vitro conditions for differentiating and culturing human mast cells, the identification of different types of human mast cells, and the creation of immunoassays for tryptases that are now used clinically to facilitate the diagnosis of systemic mastocytosis and systemic anaphylaxis.


Wayne Shreffler, MD, PhD
Dr. Shreffler is currently an Associate Professor of Pediatrics and Chief, Pediatric Allergy and Immunology at the Massachusetts General Hospital, Boston. Prior to joining MGH in 2009, he was at the Jaffe Food Allergy Institute of Mount Sinai School of Medicine, where he established himself as a leading young researcher in immune mechanisms of food allergy and asthma. Dr. Shreffler received his MD and PhD degrees from New York University and his Pediatrics training at the Albert Einstein College of Medicine. He has developed a highly integrated research and clinical program to better understand the pathogenic mechanisms of food allergy and asthma and provide the best current and future care. The Shreffler laboratory focuses on the characterization of cellular and humoral immune response to dietary antigens and the mechanisms of allergen-induced Th2 sensitization and oral tolerance. The Food Allergy Center at MGH, directed by Dr. Shreffler, conducts numerous single- and multiple-center clinical trials focused on food allergy in children and adults.


Michael Wechsler, MD MMSc
Michael Wechsler is Professor of Medicine and Director of the Asthma Program in the Division of Pulmonary, Critical Care and Sleep Medicine at National Jewish Health in Denver. He is board certified in both Pulmonary and Critical Care Medicine. Dr. Wechsler’s research focuses on clinical and translational asthma with emphasis on clinical trials in asthma, novel asthma therapies, bronchial thermoplasty, asthma pharmacogenomics, and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss Syndrome). Professor Wechsler is a member of the Steering Committee and site Principal Investigator of the NIH-sponsored Asthma Clinical Research Network (now called AsthmaNet), a multicenter asthma clinical trials consortium and a number of other multicenter clinical trials. Dr. Wechsler also serves as Associate Editor of the Journal Allergy and is on the editorial Board of the European Journal of Clinical Investigation. Dr. Wechsler received AB and MMSc degrees from Harvard University in Boston and an MD degree from McGill University in Montreal.


Ramona Doyle, MD

Dr. Doyle is currently Vice President at the California Institute for Regenerative Medicine (CIRM) where she oversees the funding and development of cell based therapies across multiple disease areas. Prior to her appointment to CIRM, Dr. Doyle was at Genentech where she built and led a global team of scientists and physicians in respiratory and allergic diseases, including the conduct of global phase II and phase III trials which led to the successful NDA for Xolair (previously approved for asthma) for chronic idiopathic urticaria, the integration of Intermune following its $8 billion acquisition and multiple global trials of lebrikizumab, an anti-IL13 monoclonal antibody. Prior to her tenure at Genentech, Ramona was a director in medical affairs at Gilead Sciences. Before moving to industry Dr. Doyle held a faculty appointment in the Department of Medicine at Stanford University for 12 years where she founded and ran the adult pulmonary hypertension service. Ramona received her undergraduate degree from the University of the South (Sewanee), a second BA and MSc at Oxford, where she was a Rhodes Scholar, and her M.D. from Emory University School of Medicine.